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Related Experiment Videos

Interaction between Li, Ni and Sr content in human cancellous bone

M Knuuttila, R Lappalainen, S Lammi

    Chemico-Biological Interactions
    |May 1, 1982
    PubMed
    Summary

    Lithium (Li), strontium (Sr), and nickel (Ni) levels in human bone show significant interrelations. These elemental concentrations in cancellous bone are not affected by chronic immobilizing diseases or age.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Bone Metabolism

    Background:

    • Bone mineral composition is crucial for skeletal health.
    • Understanding trace element dynamics in bone is essential for diagnosing and treating bone diseases.
    • Lithium, strontium, and nickel are trace elements with potential roles in bone mineralization.

    Purpose of the Study:

    • To investigate the concentrations of lithium (Li), strontium (Sr), and nickel (Ni) in human cancellous bone.
    • To determine the relationships between Li, Sr, and Ni and other elemental compositions in bone.
    • To assess the impact of chronic immobilizing diseases and age on these elemental concentrations.

    Main Methods:

    • Analysis of cancellous bone specimens from 88 healthy subjects and 50 subjects with osteoporotic changes.

    Related Experiment Videos

  • Quantification of Ca, Mg, Cd, Co, Cu, Mn, Ni, Li, Pb, Sr, and Zn using atomic absorption spectrophotometry.
  • Fluoride measurement via ion-selective electrode and statistical analysis using linear multiple regression.

    • Main Results:

    • A statistically significant inverse relationship was found between nickel (Ni) and lithium (Li) concentrations.
    • A significant positive correlation was observed between strontium (Sr) and nickel (Ni) content.
    • Chronic immobilizing diseases and age did not significantly affect Li, Sr, and Ni levels in cancellous bone.

    Conclusions:

    • The strong interrelation between lithium, strontium, and nickel suggests they play a combined role in bone mineralization.
    • These elements should be analyzed concurrently to elucidate their collective impact on bone health.
    • Current findings provide baseline data for Li, Sr, and Ni in human cancellous bone.