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Related Experiment Videos

Polymorph function in asthma

J Faulkner, R A Thompson, J Morrison-Smith

    Clinical Allergy
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Asthmatics exhibit reduced polymorph movement and impaired bactericidal activity, particularly extrinsic asthmatics. This suggests potential immune dysfunction contributing to respiratory infections in asthma patients.

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    Area of Science:

    • Immunology
    • Respiratory Medicine
    • Cellular Biology

    Background:

    • Asthma is associated with increased respiratory infections.
    • Polymorphonuclear leukocytes (PMNs) play a crucial role in host defense against bacterial infections.
    • Impaired PMN function may underlie increased infection susceptibility in asthmatics.

    Purpose of the Study:

    • To investigate in vitro polymorphonuclear leukocyte (PMN) function in asthmatic patients compared to controls and patients with bacterial infections.
    • To assess PMN movement, phagocytosis, and bactericidal activity, including nitroblue tetrazolium (NBT) reduction.
    • To correlate clinical and laboratory data with PMN function in different asthma phenotypes.

    Main Methods:

    • In vitro assessment of polymorph movement, phagocytosis, and bactericidal activity.

    Related Experiment Videos

  • Nitroblue tetrazolium (NBT) reduction assay to measure intracellular enzyme activity associated with bactericidal function.
  • Computer analysis for correlations between clinical data (asthma type, IgE, eosinophils) and laboratory findings.

    • Main Results:

    • Asthmatics showed depressed polymorph movement (P < 0.05) and lower NBT reduction augmentation (P < 0.01) compared to controls.
    • Patients with bacterial infections exhibited increased NBT reduction (P < 0.001).
    • Extrinsic asthmatics had higher unstimulated NBT activity (P < 0.05) and lower augmentation response to endotoxin (P < 0.05) than intrinsic asthmatics, along with elevated IgE and eosinophils (P < 0.002).

    Conclusions:

    • Asthmatics, especially extrinsic asthmatics, may have impaired polymorphonuclear leukocyte (PMN) function.
    • This PMN dysfunction could explain the increased susceptibility to respiratory infections or prolonged recovery observed in asthmatics.
    • Further research into PMN function in asthma is warranted to explore therapeutic interventions.