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Related Experiment Videos

On aging bone loss

R B Mazess

    Clinical Orthopaedics and Related Research
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Bone density naturally declines with age, with women experiencing accelerated loss post-menopause. Trabecular bone loss rates are lower than previously assumed, starting in early adulthood.

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    Area of Science:

    • Gerontology
    • Orthopedics
    • Bone Biology

    Background:

    • Bone aging affects both compact and trabecular bone structures.
    • Previous assumptions suggested significant trabecular bone loss after menopause.

    Purpose of the Study:

    • To survey aging changes in compact and trabecular bone.
    • To re-evaluate assumptions regarding post-menopausal trabecular bone loss.

    Main Methods:

    • Utilized noninvasive methods for assessing bone density changes over the past decade.
    • Analyzed data from large sample sizes for compact bone and variable data for trabecular bone.

    Main Results:

    • Compact bone loss averages 3% per decade from age 40, with women experiencing an accelerated 9% loss per decade post-menopause (ages 45-75).

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  • Trabecular bone loss averages 6-8% per decade, beginning in young adulthood (ages 20-40) in both sexes.
  • Findings challenge the notion of substantial ongoing trabecular bone loss after menopause.

    • Conclusions:

    • The rate of trabecular bone loss may be lower and start earlier than commonly believed.
    • Implications for calcium metabolism, anatomical correlations, and fracture incidence require re-examination.