Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

OR discrimination: a new drug discrimination method

F C Colpaert, P A Janssen

    European Journal of Pharmacology
    |February 19, 1982
    PubMed
    Summary

    This study shows rats can learn drug discrimination using an OR design, distinguishing fentanyl or cocaine from saline. This method may reveal drug cue relationships missed by traditional drug-saline discrimination.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist.

    British journal of pharmacology·2009
    Same author

    Protective effect of the alpha2-adrenoceptor antagonist, dexefaroxan, against spatial memory deficit induced by cortical devascularization in the adult rat.

    Experimental neurology·2003
    Same author

    Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists.

    Neuropharmacology·2003
    Same author

    A persistent opioid-addiction state of memory.

    Behavioural pharmacology·2003
    Same author

    Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.

    Pharmacology·2003
    Same author

    Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.

    Neuropharmacology·2002

    Area of Science:

    • Behavioral pharmacology
    • Neuroscience
    • Drug discrimination studies

    Background:

    • Traditional drug discrimination methods often use a drug versus saline comparison.
    • This limits the ability to understand complex drug cue interactions.
    • Rats exhibit biases in lever responding, which can affect learning.

    Purpose of the Study:

    • To investigate the feasibility of an OR drug discrimination paradigm in rats.
    • To compare the OR method with the traditional drug-saline method for understanding drug cue properties.
    • To explore how fentanyl and cocaine are discriminated in this new paradigm.

    Main Methods:

    • Rats were trained to respond on a specific lever for food reinforcement following injections of either fentanyl (0.04 mg/kg) or cocaine HCl (10 mg/kg).
    • Responding on the alternative lever was reinforced after saline injections.
    • Acquisition and generalization data were collected to assess learning and cue properties.

    Main Results:

    • The OR discrimination task was feasible in rats, although acquisition was slow due to a bias towards the drug lever.
    • Generalization data suggested the OR method could reveal relationships between drug cues not evident with the drug-saline method.
    • Specific dose-response relationships for fentanyl and cocaine were observed.

    Conclusions:

    • The OR drug discrimination paradigm is a viable alternative to the traditional drug-saline method.
    • This approach offers potential for a more nuanced understanding of drug cue generalization.
    • Further research is warranted to explore the full capabilities of the OR method in behavioral pharmacology.

    Related Experiment Videos