A follow-up study by vitreous fluorophotometry of early retinal involvement in diabetes

A series of 25 diabetic patients who showed apparently normal fundi on ophthalmoscopy and fundus fluorescein angiography were observed by using vitreous fluorophotometry for 30 months. The results showed that the alteration of the blood-retinal barrier increased generally during the follow-up period, particularly in the diabetic patients who were under poor metabolic control. The degree of breakdown of the blood-retinal barrier was significantly associated with the duration of the diabetic disease.