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Related Experiment Videos

Postmortem formation of carbon monoxide

T Kojima, Y Nishiyama, M Yashiki

    Forensic Science International
    |May 1, 1982
    PubMed
    Summary
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    Carbon monoxide (CO) and carboxyhemoglobin (HbCO) levels were analyzed in cadavers. Postmortem CO formation is suggested from hemoglobin decomposition, with higher HbCO in body fluids during putrefaction.

    Area of Science:

    • Forensic Science
    • Toxicology
    • Biochemistry

    Background:

    • Carbon monoxide (CO) production after death has been suggested in drowned bodies.
    • Analysis of CO and carboxyhemoglobin (HbCO) in cadavers not exposed to fire is crucial for understanding postmortem changes.

    Purpose of the Study:

    • To analyze carbon monoxide (CO) and carboxyhemoglobin (HbCO) levels in blood and body cavity fluids of cadavers.
    • To investigate the origin and significance of postmortem CO formation.

    Main Methods:

    • Gas chromatography and gas chromatography-mass spectrometry were used to determine CO levels.
    • Hemoglobin (Hb) concentration was measured as cyanmethemoglobin (CNmHb).
    • HbCO levels were calculated based on CO content and CO-binding capacity.

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    Main Results:

    • CO levels in blood ranged from 0.13 to 0.87 ml/100 g, and in body cavity fluids from 0.02 to 0.80 ml/100 g.
    • HbCO levels in blood ranged from 0.3 to 6.0%, and in body cavity fluids from 2.3 to 44.1%.
    • In cases with postmortem CO formation, body cavity fluid CO levels were often higher than blood CO levels.

    Conclusions:

    • Postmortem CO in putrefied bodies likely originates from pre-existing CO in blood and CO generated by hemoglobin decomposition.
    • Interpreting HbCO levels in body cavity fluids during advanced decomposition requires comparison with blood HbCO values.