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Subplasmalemmal linear density: a mesodermal feature and a diagnostic aid

S S Mirra, M L Miles

    Human Pathology
    |April 1, 1982
    PubMed
    Summary
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    Subplasmalemmal linear density (SLD) is a surface structure primarily found on mesodermal cells. This finding suggests SLD can serve as a valuable mesodermal marker for diagnosing poorly differentiated tumors.

    Area of Science:

    • Electron Microscopy
    • Cell Biology
    • Surgical Pathology

    Background:

    • Subplasmalemmal linear density (SLD) is a surface structure observed on mononuclear phagocytes.
    • SLD has been hypothesized as a potential morphologic marker for mesenchymal or mesodermal cells.

    Purpose of the Study:

    • To investigate the utility of SLD as a mesodermal marker.
    • To evaluate the presence of SLD in various human tissues and cell types.

    Main Methods:

    • Retrospective review of human surgical pathology cases.
    • Analysis of diagnostic electron microscopy findings over a five-year period.

    Main Results:

    • SLDs were predominantly observed in cells of mesodermal origin.

    Related Experiment Videos

  • The presence of SLD was confirmed across diverse neoplastic and nonneoplastic tissues.
  • SLD was found in various cell types, including mononuclear phagocytes and histiocytes.

    • Conclusions:

    • SLD may serve as a valuable mesodermal marker for the evaluation of poorly differentiated tumors.
    • Investigating SLD in tissue histiocytes can enhance understanding of their heterogeneity.