Meningeal osteomas and chronic renal failure

Area of Science:

• Neuropathology
• Skeletal Biology
• Neurosurgery

Background:

• Osteomas are typically found in sinuses or mandible but can occur intracranially.
• Intracranial osteomas arise from the dura mater and falx cerebri, often near the superior longitudinal sinus.

Purpose of the Study:

• To determine the incidence, distribution, histologic features, and clinical correlates of intracranial osteomas.
• To investigate the potential link between meningeal osteomas and chronic renal failure.

Main Methods:

• Retrospective autopsy study of 200 consecutive adults.
• Histologic examination of meningeal ossifications and calcifications.

Main Results:

• Ten patients (5%) had meningeal osteomas, predominantly at the dural-falx junction.
• Histology revealed active bone remodeling, osteoid, osteoclasts, and osteitis fibrosa.
• 60% of patients with meningeal osteomas had concomitant renal failure, compared to 13% in the general autopsy population.

Conclusions:

• Meningeal ossifications and calcifications represent intracranial osteomas.
• Intracranial osteomas may be more prevalent than previously recognized.
• Chronic renal failure may stimulate osteoma formation in the dura mater.