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Autoanti-idiotypic lymphocytes in man
Cells with anti-idiotypic properties were detected 4-6 months following immunization with tetanus toxoid (TT), and were undetectable 10 days following a booster injection. The presence of these cells concomitantly with the normal drop of anti-TT serum titers, and their specific binding to autologous IgG--F(ab')2 anti-TT, suggests a negative feedback at the idiotypic network level.
Cells with anti-idiotypic properties were detected 4-6 months following immunization with tetanus toxoid (TT), and were undetectable 10 days following a booster injection. The presence of these cells concomitantly with the normal drop of anti-TT serum titers, and their specific binding to autologous IgG--F(ab')2 anti-TT, suggests a negative feedback at the idiotypic network level.