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Related Experiment Videos

Evidence for the Carter effect in atopy

R Happle, U W Schnyder

    International Archives of Allergy and Applied Immunology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Mothers with atopic asthma pass on more genetic predisposition for atopy to their children than fathers. This supports the Carter effect and polygenic inheritance of atopy.

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    Area of Science:

    • Immunology
    • Genetics
    • Pediatrics

    Background:

    • Atopy, a hypersensitivity reaction, shows skewed sex ratios in specific organ manifestations like asthma.
    • Atopic asthma affects males approximately twice as often as females.

    Purpose of the Study:

    • To investigate the incidence of atopic dermatitis, atopic asthma, and atopic rhinitis in children of atopic asthma patients.
    • To examine the role of parental sex in the transmission of atopic conditions.

    Main Methods:

    • Observational study analyzing the prevalence of atopic manifestations in offspring based on maternal or paternal history of atopic asthma.
    • Comparison of atopy incidence between children of affected mothers versus children of affected fathers.

    Main Results:

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    • Children of mothers with atopic asthma exhibited a higher incidence of atopic manifestations (44%) compared to children of fathers with atopic asthma (25.5%).
    • This observed difference aligns with the Carter effect, suggesting a maternal influence on genetic predisposition.

    Conclusions:

    • The findings provide further evidence for the polygenic inheritance of atopy.
    • The Carter effect, demonstrated here, highlights that women with atopic asthma may have a higher genetic threshold, leading to greater transmission of predisposing genes.