Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Initial methadone dose in treating opiate addiction

R I Wang, C Kochar, A T Hasegawa

The International Journal of the Addictions

|February 1, 1982

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells.

Kidney international·2001

Same author

[A case of patent urachus in an adult male].

Hinyokika kiyo. Acta urologica Japonica·2000

Same author

Oxalate-induced exposure of phosphatidylserine on the surface of renal epithelial cells in culture.

Journal of the American Society of Nephrology : JASN·1999

Same author

Buprenorphine maintenance treatment of opiate dependence: a multicenter, randomized clinical trial.

Addiction (Abingdon, England)·1998

Same author

Approaches for management of postoperative pain.

Mayo Clinic proceedings·1990

Same author

Choice of rating form for evaluating anxiolytics.

Psychopharmacology bulletin·1989

Same journal

Alcohol use, drug use, and well-being in older adults in Toronto.

The International journal of the addictions·1995

Same journal

Alcohol and drug misuse in the nursing home.

The International journal of the addictions·1995

Same journal

The elderly and the use of illicit drugs: sociological and epidemiological considerations.

The International journal of the addictions·1995

Same journal

Interactions between alcohol and other drugs.

The International journal of the addictions·1995

Same journal

Misuse of prescription drugs.

The International journal of the addictions·1995

Same journal

Alcoholism and dementia.

The International journal of the addictions·1995

See all related articles

Naloxone precipitated narcotic withdrawal in opiate-dependent patients. A medium dose of methadone effectively controlled withdrawal symptoms, suggesting this dose can be determined by the naloxone test for optimal treatment.

Area of Science:

Pharmacology
Addiction Medicine
Clinical Research

Background:

Narcotic withdrawal syndrome is a significant challenge in treating opiate dependence.
Accurate dosing of methadone is crucial for effective management of withdrawal symptoms.

Purpose of the Study:

To evaluate the efficacy of different methadone doses in managing naloxone-induced narcotic withdrawal.
To establish a method for determining optimal initial methadone dosage based on opiate dependence severity.

Main Methods:

Intramuscular naloxone was administered to precipitate withdrawal in opiate-dependent patients.
Withdrawal severity was objectively rated using a standardized scale.
Patients received randomized, double-blind, low, medium, or high doses of methadone over two days.

Related Experiment Videos

Methadone dose adequacy was assessed by physical response.

Main Results:

A medium dose of methadone provided optimal control of narcotic deprivation across various withdrawal score ranges.
The naloxone-induced withdrawal score correlated with the required methadone dosage for effective symptom management.

Conclusions:

The naloxone test can reliably establish the degree of opiate dependence.
A medium methadone dose is optimal for managing narcotic withdrawal, and its administration can be guided by the naloxone test results.