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Effect of photocoagulation on ocular blood flow
Investigative Ophthalmology & Visual Science
|June 1, 1982
Summary
Panretinal photocoagulation significantly reduces ocular blood flow in rabbits, particularly choroidal-retinal circulation. Partial photocoagulation showed no consistent blood flow changes.
Area of Science:
- Ophthalmology
- Retinal Research
- Ocular Circulation
Background:
- Panretinal photocoagulation (PRP) is a common treatment for proliferative diabetic retinopathy.
- Understanding its impact on ocular blood flow is crucial for patient management.
Purpose of the Study:
- To investigate the effects of full-scatter and partial-scatter PRP on ocular blood flow in animal models.
- To determine the duration of these effects on different ocular vascular beds.
Main Methods:
- Pigmented rabbits underwent full-scatter or partial-scatter PRP, with contralateral eyes serving as controls.
- Labeled microsphere impaction was used to measure blood flow in rabbits.
- Indocyanine-green-dye clearance was employed in monkeys to assess choroidal blood flow.
Main Results:
- Full-scatter PRP in rabbits led to a significant, sustained decrease in choroidal-retinal blood flow for up to 3 months.
- No significant changes in iris-ciliary body blood flow were observed post-PRP in rabbits.
- Monkeys showed a significant reduction in choroidal blood flow immediately following PRP.
Conclusions:
- Full-scatter PRP induces a substantial and lasting reduction in choroidal-retinal blood flow.
- Partial-scatter PRP did not yield consistent changes in ocular blood flow.
- PRP's impact on ocular hemodynamics warrants further investigation, especially concerning long-term effects.