Body composition measurements in normal man: the potassium, sodium, sulfate and tritium spaces in 58 adults

The aqueous phase of total body composition varies with sex, and changes with age, necessitating age, sex and method-specific normal values. Consensus has developed for the methods most suited to clinical studies. 3H20 for water, 35SO4 for ECW, 24Na for NAc, and 40K for body potassium were used in 58 normal volunteers aged 19-80, 30 men and 28 women. This report shows significant age regressions in both sexes for total body water and intracellular water, and for both Na and K when referenced to body water. Combination of these findings with the highly age related decrease in total body potassium confirms previous studies that body cell mass decreases with age. Intracellular K+ and Na+ at the zero age intercept are 130 and 14.5 for males, and 124 and 24mEq/1 for females respectively. Secular decrease in K+ and increase in Na+ concentrations in the average cell are suggested although not established. Values for normal body composition, in subjects healthy by all available criteria are in some instances age and sex dependent, but in all parameters except fat show wide normal range (SD = 7% of mean) which derive more from biological variation than from limitations of measurement precision. However, use of body water rather than weight succeeds in narrowing this wide range, and is a more logical denominator which is readily subject to accurate measurement. In serial studies of the same subject, significant changes can be measured which are well within the normal range.