Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methodological problems in characterizing an individual's plasma glucose level

K Liu, J Stamler, R Stamler

    Journal of Chronic Diseases
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Periparturient oxidative and inflammatory status and their relation to energy metabolism and performance in transition dairy cows.

    Journal of dairy science·2025
    Same author

    Antiprotons and Elementary Particles over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

    Physical review letters·2025
    Same author

    Solar Modulation of Cosmic Nuclei over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

    Physical review letters·2025
    Same author

    Properties of Cosmic Deuterons Measured by the Alpha Magnetic Spectrometer.

    Physical review letters·2024
    Same author

    Thermal deflection in neutron scattering sample environments at Oak Ridge National Laboratory.

    The Review of scientific instruments·2024
    Same author

    Temporal Structures in Positron Spectra and Charge-Sign Effects in Galactic Cosmic Rays.

    Physical review letters·2023
    Same journal

    LEPROMATOUS LEPROSY AND AUSTRALIA ANTIGEN WITH COMMENTS ON THE GENETICS OF LEPROSY.

    Journal of chronic diseases·2015
    Same journal

    HYPERLIPIDEMIA IN AN ADULT DIABETIC POPULATION.

    Journal of chronic diseases·2015
    Same journal

    ESSENTIAL TRACE METALS IN MAN: MOLYBDENUM.

    Journal of chronic diseases·2015
    Same journal

    DISTINGUISHING PHYSIOLOGIC VARIATION FROM ANALYTIC VARIATION.

    Journal of chronic diseases·2015
    Same journal

    THE PRE-THERAPEUTIC CLASSIFICATION OF CO-MORBIDITY IN CHRONIC DISEASE.

    Journal of chronic diseases·2015
    Same journal

    AORTITIS SYNDROME WITH SPECIAL REFERENCE TO ITS CLINICAL PICTURE AND ETIOLOGY.

    Journal of chronic diseases·2015
    See all related articles

    Plasma glucose levels show significant intra-individual variation, increasing misclassification risk with single measurements. Different glucose tests also yield inconsistent individual rankings, impacting study reliability.

    Area of Science:

    • Endocrinology
    • Metabolic Health
    • Biostatistics

    Background:

    • Accurate characterization of plasma glucose levels is crucial for diagnosing and managing metabolic disorders.
    • Previous studies often rely on single measurements, potentially overlooking inherent biological variability.
    • The consistency of different glucose testing methods in classifying individuals remains incompletely understood.

    Purpose of the Study:

    • To quantify the intra-individual variation in 1-hour post-load plasma glucose levels.
    • To assess the probability of misclassifying individuals based on single glucose measurements.
    • To determine if various glucose tests (fasting, 1-hr, 2-hr post-load, GTT) provide consistent individual rankings.

    Main Methods:

    • Analysis of plasma glucose data from the Chicago Peoples Gas Company (PG) and Chicago Heart Association Detection Project in Industry (CHA) studies.

    Related Experiment Videos

  • Estimation of intra- to inter-individual variance ratios for plasma glucose and other biomarkers.
  • Application of rank correlation and quintile classification analyses using data from the Chicago Coronary Prevention Evaluation Program (CPEP).

    • Main Results:

    • Intra-individual variance ratios for post-load plasma glucose were higher compared to blood pressure, heart rate, weight, and serum uric acid.
    • Estimated probabilities indicated that while intra-individual variation may not abolish strong associations, it can complicate weaker ones.
    • Fasting, 1-hr, and 2-hr plasma glucose measurements demonstrated distinct individual characterizations, suggesting method-dependent classification.

    Conclusions:

    • Significant intra-individual variation in plasma glucose levels necessitates careful consideration in study design and interpretation.
    • Single plasma glucose measurements carry a risk of misclassification, potentially affecting the identification of individuals.
    • Inconsistent individual rankings across different glucose testing methods may contribute to variability in research findings.