The effect of ascorbic acid on cutaneous and nasal response to histamine and allergen
View abstract on PubMed
Summary
This summary is machine-generated.High doses of ascorbic acid (Vitamin C) do not improve allergic rhinitis symptoms or reduce histamine skin reactions. This study found no beneficial effects of Vitamin C on allergy symptoms.
Area Of Science
- Immunology
- Allergy Research
- Nutritional Science
Background
- Ascorbic acid (Vitamin C) is a popular supplement.
- Its potential benefits for allergic conditions are often discussed.
- Scientific evidence for its efficacy in managing allergic rhinitis is limited.
Purpose Of The Study
- To evaluate the effect of ascorbic acid (AA) on skin and nasal allergic responses.
- To determine if AA can modulate the wheal and flare response to histamine and allergens.
- To assess the dose-response relationship of AA on histamine skin tests.
Main Methods
- Eight adults with seasonal allergic rhinitis received 2 gm/day of AA or placebo for 3 days.
- Skin wheal and flare responses to histamine and allergen were measured.
- Nasal response to allergen was also assessed.
- A separate dose-response study used 0, 1, 2, and 4 gm/day of AA in six subjects.
Main Results
- No significant difference in skin or nasal reactivity was observed between AA and placebo regimens.
- Ascorbic acid, even at high doses (up to 4 gm/day), did not suppress histamine skin responses.
- The study found no beneficial effects of AA on symptoms from allergen exposure.
Conclusions
- Ascorbic acid (AA) at doses up to 4 gm/day does not appear to offer significant benefits for managing symptoms of seasonal allergic rhinitis.
- AA does not suppress the histamine-induced skin response in individuals with allergic rhinitis.
- Further research may be needed, but current findings suggest limited therapeutic value of AA for this condition.