Ultrastructural changes in skeletal muscles in dengue virus-infected mice

Dengue type 2 virus was inoculated intracerebrally in 20 adult swiss albino mice. Thigh muscles were removed after 24 h 3, 5 and 7 days after virus inoculation. Electron microscopic studies of the striated muscles show destruction of myofibrils, rarification of the sarcoplasmic reticulum network and changes in the mitochondria. Aggregates of electron-dense material as well as glycogen particles were also seen in the cytoplasm.