Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Squamous cell carcinoma with sarcomatoid stroma

S J Deshotels, D Sarma, F Fazio

    Journal of Surgical Oncology
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cytofluorimetric study of cerebrospinal fluid at staging of diffuse large B cell lymphoma.

    Journal of chemotherapy (Florence, Italy)·2026
    Same author

    Refining the role of selinexor in multiple myeloma: strategic use in a shifting treatment landscape.

    ESMO open·2026
    Same author

    Preliminary insights on the daily rhythm of CRP and IL-6 in athletic horses.

    Journal of equine veterinary science·2025
    Same author

    Corrigendum to "First-line therapy with daratumumab, lenalidomide and dexamethasone for patient with POEMS syndrome: A case report" [Leukemia Research Reports (2024) Volume 22, 100491].

    Leukemia research reports·2025
    Same author

    Investigation of the impact of seasonal climate conditions on feed intake and body weight in horses.

    International journal of biometeorology·2025
    Same author

    First-line therapy with daratumumab, lenalidomide and dexamethasone for patient with POEMS syndrome: A case report.

    Leukemia research reports·2024

    Squamous cell carcinoma with sarcomatoid stroma presents diagnostic challenges. Ultrastructural analysis revealed distinct origins for spindle cells in two rare upper airway tumors.

    Area of Science:

    • Oncology
    • Pathology
    • Head and Neck Cancer Research

    Background:

    • Squamous cell carcinoma (SCC) can exhibit sarcomatoid changes, posing diagnostic difficulties.
    • Understanding the cellular origins of sarcomatoid stroma in SCC is crucial for accurate classification and treatment.
    • Rare tumors of the upper respiratory and gastrointestinal tracts require detailed investigation.

    Observation:

    • Two cases of SCC with sarcomatoid stroma were analyzed.
    • Case 1: Soft palate SCC metastasized to a neck lymph node. Both epithelial and spindle cell components showed ultrastructural features of SCC.
    • Case 2: Laryngeal SCC with spindle cell stroma. Ultrastructural studies indicated proliferating fibroblasts, not of carcinomatous origin.

    Findings:

    • Ultrastructural examination confirmed the epithelial and spindle cell components of the primary and metastatic tumor in Case 1 were both SCC.

    Related Experiment Videos

  • In Case 2, the spindle cell stroma of the laryngeal SCC was identified as proliferating fibroblasts.
  • These findings highlight the heterogeneity of sarcomatoid stroma in SCC.

    • Implications:

    • The distinct origins of sarcomatoid components necessitate careful diagnostic evaluation.
    • Accurate classification based on ultrastructural analysis is vital for predicting tumor behavior.
    • Further research into these rare entities may refine diagnostic criteria and therapeutic strategies for upper airway and upper GI tract cancers.