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Malignant histiocytosis showing facial involvement
The Laryngoscope
|May 1, 1982
Summary
Malignant histiocytosis (MH) can manifest with facial symptoms, including sinus involvement and nerve deficits. This case highlights the importance of considering facial presentations in diagnosing this rare neoplastic proliferation.
Area of Science:
- Oncology
- Pathology
- Dermatology
Background:
- Malignant histiocytosis (MH) is a rare neoplastic proliferation of atypical histiocytes.
- Typical MH symptoms include fever, lymphadenopathy, fatigue, and malaise.
- Facial involvement in MH, while documented, is often underemphasized.
Observation:
- A 51-year-old woman presented with fever, fatigue, diplopia, and facial numbness.
- Facial roentgenogram revealed parasinusitis.
- Histologic examination of sinus biopsy showed infiltration by atypical histiocytes.
Findings:
- The patient's condition progressed rapidly, leading to death within two months.
- Autopsy confirmed systemic neoplastic proliferation of atypical histiocytes, diagnosing malignant histiocytosis.
- The case underscores significant facial involvement in MH.
Implications:
- Facial symptoms, such as sinus involvement and neurological deficits, should prompt consideration of MH.
- Increased awareness of facial manifestations can aid in earlier diagnosis of MH.
- Further investigation into the frequency and significance of facial involvement in MH is warranted.