Related Experiment Video

Updated: Sep 14, 2026

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

[Mother-transmitted antimalarial immunity. its evolution in child (author's transl)]

U Omanga, P Kageruka, M Tshishimbi

    Medecine Tropicale : Revue Du Corps De Sante Colonial
    |January 1, 1982
    PubMed

    The authors report the results of a survey and a longitudinal study of mother-transmitted antimalarial antibodies, conducted through indirect immunofluorescence tests. The data indicate that 16 p. 100 of the new-born and 25 p. 100 of the considered age group get maternal antibodies either through transplacental way of through breast-feeding. Among 99 mothers having a positive antimalarial serology at their delivery, 30 have transmitted their antibodies to their infant. But whatever the way of transmission may be, these antibodies do not last longer, as a rule, than one month. If this passive immunity is either lacking or insufficient to protect the child, it seems that HbF has a great protective role, as indicated by the concordance between its decrease and the raise of malaria morbidity in children. As a consequence of the existence of a natural protection by HbF during the first three months of life, malarial prophylaxis does not seem necessary during this period.

    More Related Videos

    Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites08:46

    Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

    Published on: May 18, 2016

    Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay09:57

    Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

    Published on: August 6, 2020

    Related Concept Videos

    Symbiosis00:58

    Symbiosis

    Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
    Animal Mitochondrial Genetics02:59

    Animal Mitochondrial Genetics

    Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
    Transcytosis of IgG01:15

    Transcytosis of IgG

    Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
    IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
    Development of Immunocompetence01:22

    Development of Immunocompetence

    The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
    The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
    Subsequent T...
    Malaria01:29

    Malaria

    Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
    Antiprotozoal Agents01:21

    Antiprotozoal Agents

    Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...