Gastroesophageal reflux and asthma: a possible reflex mechanism

Fifteen asthmatic patients with gastroesophageal reflux underwent an intraesophageal acid provocation test. Pulmonary function measurements demonstrated increased flow resistance when reflux symptoms occurred. After relief of symptoms, these changes tended to rapidly reverse. The technique employed and the prompt reversal of pulmonary functions suggest reflex mechanisms may be producing the observed bronchoconstriction.