Clofazimine in pregnancy complicated by leprosy

Little is known of the perinatal consequences of the use of clofazimine (B663, Lamprene) to treat leprosy. Two patients who were treated with the drug throughout pregnancy are presented and the literature is reviewed. Although the 2 current pregnancies ended successfully, 3 neonatal deaths in 15 pregnancies (20%) have been reported. These data suggest that patients taking clofazimine during pregnancy be managed at a perinatal center where adequate neonatal care can be given.