Clinico-chemical changes in goats given carbon tetrachloride

Six healthy castrated male goats were each given 1.0, 1.25 or 1.5 ml of carbon tetrachloride per 10 kg BW by stomach tube (2 animals at each dose level). Definite signs of dose dependant liver damage were seen, starting about 4 hours after administration of the drug. The clinico-chemical changes included increased total and conjugated plasma bilirubin, decreased blood clotting activity, and increased activities of P-ASAT and P-GT. Further experiments are needed in animals afflicted with liverflukes to establish the lowest possible anthelmintic dose of carbon tetrachloride.