[Biological properties of 11-deoxyprostaglandin E1]

A study was made of 11-desoxyprostaglandin E1 (11-desoxy-PGE1) effect on bronchial resistance, gastric secretion, indomethacin-induced ulcer in rats and adrenalin-produced lipolysis in rat epididymal adipose tissue in vitro. The drug exerted dose-dependent bronchodilator effect in doses of 1 to 100 micrograms/kg. ED50 was 18.66 micrograms/kg. The bronchodilator effect of 11-desoxy-PGE1 was 46.5 to 50.5% of alupent activity within 60 minutes and 97.8% for a period of 60 to 90 minutes. The drug administration in the presence of bronchial spasm considerably reduces the bronchodilator effect duration (down to 5 to 15 minutes). 11-desoxy-PGE1 produces dose-dependent decrease in gastric secretion (ED50 = 4000 micrograms/kg) and hydrogen ion concentration in rat gastric juice (ED50 = 2000 micrograms/kg). The use of 1-desoxy-PGE1 in rats prior to indomethacin injection protects the gastric mucosa, diminishing erosion number. ED50 was equal to 50 micrograms/kg. The drug exerts inhibitory effect on adrenalin-induced lipolysis of the epididymal adipose tissue in vitro. The most pronounced action of 11-desoxy-PGE1 is its bronchodilator effect manifesting after the minimum dose use (1 microgram/kg).