Antiinflammatory and antiproteolytic properties of substituted tetrazolycarbamides

Eight 1-(5-aryl-2-acetyltetrazolyl)-3-substituted carbamides were evaluated for their antiinflammatory and antiproteolytic properties. The protection afforded by these compounds (100 mg/Kg, i.p.) against carrageenin-induced edema in rats ranged from 10-45%. Oxyphenbutazone (40 mg/kg, i.p.) and hydrocortisone (10 mg/kg, i.p.), used as reference drugs, possessed 53% and 45% antiinflammatory activity, respectively. All substituted tetrazolyl carbamides (1 mM) possessed antiproteolytic activity which was reflected by their ability to inhibit the activity of trypsin during hydrolysis of bovine serum albumin. The degree of protection observed against trypsin-induced hydrolysis ranged from 25-62% while such an inhibition with sodium salicylate (1 mM) was 52%.