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Immunological changes in canine cruciate ligament rupture
Research in Veterinary Science
|March 1, 1982
Summary
Immune complexes (IC) were found in most dogs with stifle joint inflammation and anterior cruciate ligament rupture (CLR). This suggests immunological mechanisms are involved in canine CLR.
Area of Science:
- Veterinary Immunology
- Canine Orthopedics
Background:
- Inflammatory arthropathy and anterior cruciate ligament rupture (CLR) are common in dogs.
- The role of immune complexes in canine joint disease is not fully understood.
Purpose of the Study:
- To investigate the presence of C1q-binding immune complexes (IC) in dogs with inflammatory arthropathy of the stifle joints, particularly those with CLR.
- To explore potential immunological mechanisms associated with canine CLR.
Main Methods:
- Solid phase radioimmunoassay was used to detect C1q-binding IC in sera and synovial fluid from affected dogs and healthy controls.
- Sera were also tested for anticollagen antibodies and rheumatoid factor.
Main Results:
- Significant concentrations of IC were detected in 79% of sera and 69% of synovial fluid samples from dogs with inflammatory arthropathy and CLR.
- Anticollagen antibodies were not detected, but rheumatoid factor was present in a small percentage of samples.
- Healthy control dogs showed no significant IC levels.
Conclusions:
- The presence of IC in canine stifle joint inflammatory conditions, especially with CLR, indicates active immunological involvement.
- Immunological mechanisms likely contribute to the pathogenesis of CLR in dogs.