Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Development of small intestinal neomucosa]

F Nöthiger, I Oesch, A Zimmermann

    Schweizerische Medizinische Wochenschrift
    |April 12, 1982
    PubMed
    Summary

    Researchers created a rat model where colon tissue formed a pouch lined with epithelium, demonstrating potential for increasing intestinal surface area after resection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Conserving large populations of lions - the argument for fences has holes.

    Ecology letters·2013
    Same author

    Fibrolamellar variant of hepatocellular carcinoma does not have a better survival than conventional hepatocellular carcinoma--results and treatment recommendations from the Childhood Liver Tumour Strategy Group (SIOPEL) experience.

    European journal of cancer (Oxford, England : 1990)·2013
    Same author

    Transverse momentum distribution and nuclear modification factor of charged particles in p+Pb collisions at sqrt[s(NN)] = 5.02 TeV.

    Physical review letters·2013
    Same author

    Ambiguous genitalia and hypertension in a patient with congenital adrenal hyperplasia.

    Internal medicine journal·2013
    Same author

    Charge separation relative to the reaction plane in Pb-Pb collisions at sqrt[s(NN)] = 2.76 TeV.

    Physical review letters·2013
    Same author

    Pseudorapidity density of charged particles in p+Pb collisions at √(s(NN))=5.02 TeV.

    Physical review letters·2013

    Area of Science:

    • Gastroenterology
    • Surgical Innovation
    • Tissue Engineering

    Context:

    • Epithelial growth on peritoneal surfaces can occur under specific conditions.
    • Extensive small bowel resection presents challenges in maintaining adequate absorptive surface area.
    • Developing functional intestinal tissue is crucial for managing gastrointestinal disorders.

    Purpose:

    • To develop a novel surgical model in rats to investigate epithelialization of peritoneal surfaces.
    • To create a functional pouch capable of supporting normal small bowel passage.
    • To assess the potential of this model for clinical applications in patients with short bowel syndrome.

    Summary:

    • A seromuscular tunnel was constructed by folding rat colon and suturing it to the ileum.
    • After 6-12 weeks, a pouch formed with a developed one-layer cylindric epithelium exhibiting disaccharidase activity.
    • This demonstrates successful in-vivo tissue regeneration and functionalization.

    Impact:

    • This model provides a platform for studying peritoneal-based epithelial regeneration.
    • It offers a potential strategy to augment mucosal surface area in the remaining small bowel post-resection.
    • The findings could lead to improved treatments for malabsorption syndromes and short bowel syndrome.

    Related Experiment Videos