Effects of hypoxemia upon aminoglycoside serum pharmacokinetics in animals

Hypoxemia causes significant alterations in aminoglycoside serum pharmacokinetics in adult rats and newborn rabbits. The aminoglycoside serum clearances were diminished in hypoxemic animals. Comparisons of intravenous and intramuscular administration imply a delay in uptake of drug from intramuscular injection sites under hypoxemic conditions.