Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nafcillin therapy for Staphylococcus aureus endocarditis

H Masur, H W Murray, R B Roberts

    Antimicrobial Agents and Chemotherapy
    |September 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Major barriers and facilitators of care for patients with infectious complications of opioid use disorder: A multi-site, qualitative analysis of expert stakeholders from the CHOICE protocol.

    Journal of substance use and addiction treatment·2025
    Same author

    Achieving sustained virologic response after interferon-free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis.

    Journal of viral hepatitis·2016
    Same author

    Hepatic compartmentalization of exhausted and regulatory cells in HIV/HCV-coinfected patients.

    Journal of viral hepatitis·2014
    Same author

    Baseline CD4+ T-cell counts predict HBV viral kinetics to adefovir treatment in lamivudine-resistant HBV-infected patients with or without HIV infection.

    HIV clinical trials·2013
    Same author

    Effect of HIV on liver fibrosis among HCV-infected African Americans.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2013
    Same author

    Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells.

    Journal of viral hepatitis·2012
    Same journal

    Isavuconazole for invasive mold disease in patients with hematological malignancies: a multicenter real-world study from China on efficacy, safety, and competing risks.

    Antimicrobial agents and chemotherapy·2026
    Same journal

    An Achilles' heel for methicillin-resistant <i>Staphylococcus aureus</i>? Re-evaluating β-lactam susceptibility of MRSA.

    Antimicrobial agents and chemotherapy·2026
    Same journal

    Essential role of glycogen synthase kinase 3 in regulating growth, drug response, and infectivity in <i>Leishmania infantum</i>.

    Antimicrobial agents and chemotherapy·2026
    Same journal

    <i>In vitro</i> antibacterial activity of gepotidacin in combination with other antimicrobial agents against <i>Neisseria gonorrhoeae</i> isolates.

    Antimicrobial agents and chemotherapy·2026
    Same journal

    Development of domain-specific probes of <i>Plasmodium falciparum</i> heat shock protein 70-1.

    Antimicrobial agents and chemotherapy·2026
    Same journal

    Addressing therapeutic options for KPC-3-producing ST307-<i>Klebsiella pneumoniae</i>: insights from <i>in vitro</i> evolution and mutant prevention strategies.

    Antimicrobial agents and chemotherapy·2026
    See all related articles

    Nafcillin is effective for Staphylococcus aureus endocarditis, especially in heroin addicts. Methicillin showed similar efficacy but with more adverse reactions like nephritis, making nafcillin the preferred choice.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Cardiology

    Background:

    • Semisynthetic penicillinase-resistant penicillins are standard for Staphylococcus aureus endocarditis.
    • Limited data exist on the comparative efficacy and safety of individual agents.

    Purpose of the Study:

    • To evaluate the efficacy and safety of nafcillin and methicillin in treating Staphylococcus aureus endocarditis.
    • To compare adverse reactions between nafcillin and methicillin.

    Main Methods:

    • Retrospective analysis of patients treated with nafcillin or methicillin for Staphylococcus aureus endocarditis.
    • Clinical and bacteriological outcomes were assessed.
    • Adverse reactions were documented.

    Main Results:

    Related Experiment Videos

    • Nafcillin showed high efficacy in heroin addicts with S. aureus endocarditis.
    • Methicillin achieved bacteriological cure in most patients but was associated with nephritis.
    • Adverse reactions included leukopenia and rash with nafcillin; nephritis and rash with methicillin.

    Conclusions:

    • Nafcillin is a highly efficacious treatment for S. aureus endocarditis, with outcomes comparable to other agents.
    • Nafcillin is considered preferable to methicillin due to a lower incidence of severe adverse reactions.
    • Nafcillin demonstrates a favorable safety and efficacy profile for S. aureus endocarditis therapy.