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Related Experiment Videos

[Clofibrate therapy--the status quo]

W Reuter

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |January 15, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Clofibrate, containing clofibric acid, is a long-standing, effective lipid-lowering drug that reduces cardiovascular risks. While beneficial for triglyceride and cholesterol metabolism, it may increase the risk of gallstones.

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    Area of Science:

    • Pharmacology
    • Metabolic Medicine
    • Cardiovascular Research

    Context:

    • Clofibrate is a well-established lipid-lowering medication.
    • It significantly impacts triglyceride and cholesterol metabolism.
    • Its efficacy in reducing cardiovascular events is supported by follow-up studies.

    Purpose:

    • To detail the role of clofibric acid as the active component of clofibrate.
    • To outline clofibrate's metabolic effects and clinical applications.
    • To highlight potential side effects and specific indications for its use.

    Summary:

    • Clofibrate, with clofibric acid as its active substance, is a highly effective and long-used lipid-decreasing agent.
    • It influences both triglyceride and cholesterol metabolism, demonstrably reducing coronary morbidity and mortality.

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  • A potential side effect is an increased incidence of gallstones, with specific indications for hypertriglyceridemia and refractory hypercholesterolemia.

    • Impact:

    • Provides a comprehensive overview of clofibrate's therapeutic profile.
    • Informs clinical decisions regarding its use in managing dyslipidemias.
    • Contributes to understanding the risk-benefit balance of clofibrate therapy.