Immunisation of mice against Strongyloides ratti

Experimental infections of C57Bl/6 mice with strongyloides ratti produced marked resistance to challenge. Resistance to reinfection was induced by as few as six filariform larvae. The degree of resistance produced by soluble somatic antigens prepared from filariform larvae of S. ratti was comparable to that seen after a primary infection. The addition of Freund's adjuvants to the antigen did not increase resistance significantly. Intraperitoneal implantation of micropore chambers containing filariform larvae failed to induce resistance to reinfection. Considerable resistance to a challenge infection with S. ratti was found after infection with S. stercoralis.