Peculiarities of serotonin metabolism during allergic reactions

Patients with mixed, infectious-allergic bronchial asthma and allergodermatoses showed suppression of serotonin metabolism. Allergic reactions in experimental animals were accompanied by changes in the activity of 5-hydroxytryptophandecarboxylase, mitochondrial and blood serum monoaminoxydase, and ceruloplasmin. These changes differed during primary and repeated anaphylactic shock. Quantitative changes in tissue serotonin varied with the activity of the enzymes taking part in its metabolism. During the 1st, 2nd, 5th and 7th days of the post-shock period, serotonin metabolism did not return to normal.