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Integrated calculator programs for pharmacokinetic calculations

R A Robb, L A Bauer, J R Koup

    American Journal of Hospital Pharmacy
    |May 1, 1982
    PubMed
    Summary
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    This study introduces integrated pharmacokinetic programs for a HP-41C calculator, enabling efficient drug dosing calculations in hospital pharmacy. These programs offer a reliable tool for applying pharmacokinetic principles in clinical practice.

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Computational Chemistry

    Background:

    • Calculating pharmacokinetic variables and drug-dosing regimens is crucial for effective patient treatment.
    • Existing methods for these calculations can be time-consuming and prone to error in a clinical setting.
    • The need for accessible and rapid computational tools in hospital pharmacy practice is well-established.

    Purpose of the Study:

    • To develop and describe a package of integrated programs for a hand-held programmable calculator.
    • To facilitate the calculation of pharmacokinetic variables and drug-dosing regimens.
    • To provide a practical tool for hospital pharmacists to apply pharmacokinetic principles.

    Main Methods:

    • Development of twelve pharmacokinetic programs based on established pharmacokinetic equations.

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  • Implementation of these programs on an HP-41C hand-held calculator.
  • Inclusion of programs for drug-specific calculations (e.g., digoxin, theophylline, phenytoin, aminoglycosides) and patient parameters (ideal body weight, body surface area, creatinine clearance).

    • Main Results:

    • A functional package of 12 integrated pharmacokinetic programs was created for the HP-41C calculator.
    • Eleven programs can be stored simultaneously, with data transferable between programs.
    • The calculator's continuous memory ensures data and program retention when powered off.

    Conclusions:

    • The integrated calculator programs offer a quick, reliable, and accessible method for pharmacokinetic calculations.
    • This tool enhances the application of pharmacokinetic principles in daily hospital pharmacy practice.
    • The system supports efficient and accurate drug dosing and patient management.