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CK-MB isoenzyme in patients with polymyositis
The American Journal of the Medical Sciences
|May 1, 1982
Summary
Serum creatine kinase isoenzyme (CK-MB) levels can help differentiate polymyositis from myocardial infarction. Persistent CK-MB elevation indicates polymyositis, unlike the transient rise seen in heart attacks.
Area of Science:
- Biochemistry
- Clinical Diagnostics
- Immunology
Background:
- Polymyositis is an inflammatory myopathy.
- Distinguishing polymyositis from myocardial infarction can be challenging due to overlapping symptoms.
- Creatine kinase (CK) and its isoenzymes are biomarkers for muscle and heart damage.
Observation:
- Five polymyositis patients were analyzed for total serum creatine kinase and isoenzyme levels.
- CK-MB isoenzyme was detected in all polymyositis patients using chromatography and electrophoresis.
- No evidence of myocardial infarction was present in these patients.
Findings:
- Persistent elevation of CK-MB was observed in polymyositis patients.
- This contrasts with the typically transient increase of CK-MB in myocardial infarction.
- Serial CK-MB quantitation can differentiate between polymyositis and myocardial infarction.
- CK-MB is a sensitive monitoring tool, comparable to total CK, but more so than AST and LDH.
Implications:
- CK-MB isoenzyme analysis provides a valuable diagnostic tool for polymyositis.
- This method aids in differentiating inflammatory myopathies from cardiac events.
- Serial CK-MB monitoring can guide clinical management and diagnosis in suspected cases.