Related Experiment Videos
Leiomyomas: steroid receptor content. Variation within normal menstrual cycles
American Journal of Obstetrics and Gynecology
|May 1, 1982
Summary
Ovarian function influences uterine leiomyomas. Researchers found that estrogen and progesterone receptor levels in leiomyomas change cyclically with the menstrual cycle, mirroring changes in the endometrium and myometrium.
Area of Science:
- Reproductive endocrinology
- Gynecologic oncology
- Tumor biology
Background:
- Uterine leiomyomas are common benign tumors.
- Their growth is influenced by ovarian hormones.
- The precise relationship between ovarian function and leiomyoma receptor content requires further clarification.
Purpose of the Study:
- To investigate the relationship between ovarian function and uterine leiomyoma.
- To analyze cytoplasmic estrogen and progesterone receptor content in leiomyomas.
- To compare receptor level changes in leiomyomas with those in normal uterine tissues during the menstrual cycle.
Main Methods:
- Studied 17 women of reproductive age during ovulatory menstrual cycles.
- Measured serum estrogen and progesterone levels.
- Analyzed cytoplasmic estrogen and progesterone receptor content in endometrial, myometrial, and leiomyoma tissues.
Main Results:
- Cytoplasmic estrogen and progesterone receptor levels in leiomyomas exhibited cyclic changes throughout the menstrual cycle.
- These changes in leiomyomas mirrored those observed in the endometrium and myometrium.
- Receptor level fluctuations in leiomyomas correlated with circulating estrogen and progesterone variations.
Conclusions:
- Uterine leiomyomas possess estrogen and progesterone receptors that respond to hormonal fluctuations.
- Ovarian function, specifically cyclical hormonal variations, appears to influence receptor content in leiomyomas similarly to normal uterine tissues.
- This suggests a hormonal sensitivity of leiomyomas throughout the menstrual cycle.