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Related Experiment Videos

Apneusis

C Shim, M H Williams

    Archives of Internal Medicine
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    This study reports two unusual cases of apneustic breathing in conscious patients with intact vagal function. Findings suggest experimental models may not fully represent human apneustic breathing mechanisms.

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    British medical journal·2010

    Area of Science:

    • Neurology
    • Respiratory Physiology

    Background:

    • Apneustic breathing, characterized by prolonged inspiration, is typically studied in experimental models.
    • Understanding its mechanisms in humans is crucial for diagnosing and managing respiratory disorders.

    Observation:

    • Two patients presented with unique apneustic breathing patterns, differing from experimental observations.
    • Both patients maintained alertness and consciousness with intact vagal nerve function.
    • Respiratory rhythms featured predominantly inspiratory holds with a smooth background.

    Findings:

    • Apneustic frequency and duration were unaffected or decreased with carbon dioxide (CO2) breathing.
    • Hyperventilation increased apneustic events in one patient.
    • One patient had a history of narcotic abuse; the other had long-standing deafness and mutism post-meningitis.

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    Implications:

    • The observed variations challenge the direct applicability of experimental apneusis models to human cases.
    • These findings highlight the need for further research into the diverse pathophysiological mechanisms of human apneustic breathing.
    • Clinical presentation and neurological status significantly influence the manifestation of apneustic breathing.