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Published on: October 12, 2017
[Vesicoureteral reflux in the first year of the life (author's transl)]
Insights
Vesicoureteric reflux (VUR) in children is linked to kidney scarring and growth issues, with higher VUR grades correlating with worse outcomes. Absence of urinary tract infections (UTI) aids VUR resolution in some cases.
Area of Science:
- Pediatric Nephrology
- Urology
Context:
- Vesicoureteric reflux (VUR) affects infants and is graded by severity.
- Longitudinal studies are crucial for understanding VUR's impact on renal health.
Purpose:
- To investigate the relationship between VUR grade, clinical evolution, and renal scarring in children.
- To determine the influence of urinary tract infections (UTI) on VUR resolution and renal growth.
Summary:
- Follow-up of 50 children with VUR revealed a correlation between VUR grade and renal scarring/growth.
- Grade 3 VUR resolution was influenced by the absence of UTI, unlike Grade 2.
- UTI impacted renal growth in scarred kidneys with Grade 3 VUR; no new scars formed in initially normal kidneys.
Impact:
- Findings highlight the prognostic significance of VUR grading for renal damage.
- Understanding UTI's role can inform management strategies to preserve renal function.
- Early identification and monitoring of VUR are vital for preventing long-term kidney complications.
Abstract:
A group of 50 children in the first year of life with vesicoureteric reflux (VUR) has been followed-up for a period of two-eleven years. VUR has been classified in four grades according to Hertz's criteria. Clinical evolution and renal scarring have been related to the degree of VUR. The absence of urinary tract infection (UTI) influences disappearance of the VUR grade 3 but does not influence the disappearance of VUR grade 2. There is a statistically significant correlation between renal scarring, the degree of VUR and renal growth. UTI influences renal growth in scarred kidneys with VUR grade 3. No scars have been seen in previously normal kidneys in the first radiological examination.
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