Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clindamycin passage into human milk

B Stéen, A Rane

    British Journal of Clinical Pharmacology
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Clindamycin transfers into breast milk, with levels varying significantly between mothers. Due to potential infant risks, nursing is not recommended during clindamycin treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Measurements of jet multiplicity and jet transverse momentum in multijet events in proton-proton collisions at <math></math>.

    The European physical journal. C, Particles and fields·2023
    Same author

    Azimuthal Correlations within Exclusive Dijets with Large Momentum Transfer in Photon-Lead Collisions.

    Physical review letters·2023
    Same author

    Measurement of the mass dependence of the transverse momentum of lepton pairs in Drell-Yan production in proton-proton collisions at <math></math>.

    The European physical journal. C, Particles and fields·2023
    Same author

    Measurements of the associated production of a W boson and a charm quark in proton-proton collisions at <math> </math>.

    The European physical journal. C, Particles and fields·2022
    Same author

    Search for Higgs Boson Pair Production in the Four b Quark Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

    Physical review letters·2022
    Same author

    Search for Flavor-Changing Neutral Current Interactions of the Top Quark and Higgs Boson in Final States with Two Photons in Proton-Proton Collisions at sqrt[s]=13  TeV.

    Physical review letters·2022
    Same journal

    N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

    British journal of clinical pharmacology·2026
    Same journal

    The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

    British journal of clinical pharmacology·2026
    Same journal

    Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

    British journal of clinical pharmacology·2026
    Same journal

    UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

    British journal of clinical pharmacology·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Maternal and Infant Health
    • Infectious Diseases

    Background:

    • Puerperal infections require antibiotic treatment, with clindamycin being a common choice.
    • Understanding drug transfer into breast milk is crucial for infant safety.
    • Clindamycin's pharmacokinetic profile in lactating women needs further elucidation.

    Purpose of the Study:

    • To quantify clindamycin bioactivity in maternal plasma and breast milk.
    • To assess the interindividual variability of clindamycin levels.
    • To determine the relationship between plasma and milk concentrations of clindamycin.

    Main Methods:

    • Bioactivity assays were performed on plasma and breast milk samples from women with puerperal infections.
    • Samples were collected throughout the dosage interval.

    Related Experiment Videos

  • Correlations between plasma and milk concentrations were analyzed.

    • Main Results:

    • Significant interindividual variations in peak clindamycin plasma levels were observed.
    • Clindamycin bioactivity in breast milk varied widely, ranging from 1/10 to several times the concurrent plasma levels.
    • Milk clindamycin concentration at the end of the dosage interval correlated with the area under the plasma concentration-time curve.

    Conclusions:

    • Clindamycin is transferred into human breast milk.
    • While secreted amounts may be low, potential side effects and unknown effects on neonates warrant caution.
    • Nursing is advised against during clindamycin therapy due to safety concerns for the infant.