Role of the H-2 complex in preimplantation mouse embryo development

The H-2 complex was found to influence early mouse embryo development. Slow development was shown to be associated with the H-2k haplotype. By the use of congenic strains, it was clearly demonstrated that gene(s) in the H-2 complex affect the time of the first cleavage division and the rate of subsequent preimplantation development