Related Experiment Video
Updated: May 28, 2026
08:43
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Ta and T1 bladder cancer: location, recurrence and progression
British Journal of Urology
|April 1, 1982
Summary
First superficial bladder tumors (Ta or T1) with lamina propria invasion, multiplicity, or large size increase recurrence risk. Initial tumor multiplicity also predicts progression to higher grade or stage bladder cancer.
Area of Science:
- Uro-oncology
- Cancer research
- Clinical urology
Background:
- Superficial bladder cancer (stages Ta and T1) accounts for the majority of new bladder cancer diagnoses.
- Recurrence and progression are significant concerns in managing superficial bladder tumors, necessitating identification of predictive factors.
- Understanding risk factors for new tumor occurrence and progression is crucial for optimizing patient surveillance and treatment strategies.
Purpose of the Study:
- To identify clinical and pathological factors associated with the occurrence of new superficial bladder tumors.
- To determine predictors of tumor progression (development of higher grade or stage) in patients with initial superficial bladder tumors.
- To analyze the location of initial versus subsequent tumor occurrences.
Main Methods:
- Prospective analysis of 58 patients with first-time superficial bladder tumors (stage Ta or T1).
- Evaluation of tumor characteristics including invasion, multiplicity, size, and biopsy findings.
- Correlation of urinary cytology and tumor grade with new tumor development and progression.
Main Results:
- Tumor characteristics strongly predicting new tumor occurrence included lamina propria invasion, multiplicity, size (≥3 cm), and abnormal mucosal biopsies.
- Positive urinary cytology and higher tumor grade showed a weaker correlation with new tumor occurrence.
- Initial tumor multiplicity was associated with the development of higher grade or stage subsequent tumors (progression).
- While initial tumors were seldom on the dome (5.2%), new tumors occurred on the dome in 29% of patients.
Conclusions:
- Specific initial tumor characteristics are key indicators for the risk of new superficial bladder tumor development.
- Initial tumor multiplicity is a significant predictor of subsequent tumor progression in stage Ta or T1 bladder cancer.
- The bladder dome represents a site of increased risk for new tumor occurrences compared to initial tumor locations.
Related Concept Videos
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...