Solitary bony metastasis to the foot with long survival following amputation

A 73-year-old man developed a solitary metastasis to the cuboid bone of the foot one year after a left upper lobectomy for bronchogenic adenosquamous carcinoma. Irradiation controlled the pain for 1 1/2 years. Metastatic work-up failed to show other foci; hence, a Syme's amputation was performed. The patient remains well with no evidence of disease 3 1/2 years after biopsy diagnosis. Metastasis to the peripheral bones of the feet are extremely rare. Only 23 biopsy-proven cases are recorded in the English literature, seven of which were of bronchogenic origin. Most of the cases were part of disseminated metastatic disease, with the longest reported survival being 26 months. The present case had an apparently solitary metastasis, with a relatively long survival of 44 months following diagnosis.