Related Experiment Video
Updated: Aug 6, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Duodeno-gastric reflux in normal and dyspeptic subjects
Abstract:
A simple radiological technique is described for detecting the presence, or absence, of duodeno-gastric reflux (DGR) at barium meal examination. The incidence of DGR was found to be approximately the same in both normal volunteers and dyspeptic patients. Although there was a slight trend towards an increased incidence in gastric ulcer, this did not reach statistical significance. The severity of reflux did not correlate with the presence of peptic ulceration. DGR appears to be more common with increasing age. Our results cast doubt on the hypothesis that reflux of duodenal content plays a primary role in the pathogenesis of gastric ulcer.
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Gastroesophageal Reflux Disease

