Phototoxicity to benoxaprofen

Photosensitization to benoxaprofen has been studied in human volunteers. The wavelengths that mediate the reaction lie mainly just outside the sunburn range in the near ultraviolet, UVA region including, however the terminal portion of the UVB region. The photosensitivity reaction begins with sharp burning during exposure, sometimes accompanied by itching. This may be followed by erythema and a flare, which generally fade in about one hour or less. High doses of ultraviolet light can elicit whealing. Photosensitivity to benoxaprofen is typically an immediate-type, short-lived reaction, dominated by subjective sensations of burning-smarting and redness. With large UVA doses, a sunburn-type reaction may also be present at 24 hours. The photosensitivity is of the phototoxic type. It may appear within 48 hours of starting the drug and usually disappears with 48 hours after stopping. The population most at risk are type 1 and type 2 light-skinned persons who burn easily and tan poorly. Pigmented races are quite resistant, viz, blacks and orientals. Dark-skinned type 4 Caucasoids, such as Mexicans, Indians, etc., have high innate protection. Deep tanning and SPF 15 sunscreens provide adequate protection.