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Plasma ascorbic acid levels in premature infants

I D Arad, E Sagi, F G Eyal

    International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
    |January 1, 1982
    PubMed
    Summary

    Premature newborns may develop vitamin C deficiency due to limited feeding. Ensuring adequate vitamin C intake is crucial for maintaining healthy plasma ascorbate levels in these vulnerable infants.

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    Area of Science:

    • Neonatology
    • Nutritional Science
    • Biochemistry

    Background:

    • Fetal vitamin C levels are high, but postnatal provision can be inadequate.
    • Premature newborns often experience delayed alimentation, increasing risk of ascorbate deficiency.
    • Hypoascorbemia can occur in neonates due to insufficient vitamin C supply.

    Purpose of the Study:

    • To assess plasma ascorbate levels in premature newborns during the first two weeks of life.
    • To determine the impact of varying daily vitamin C intake on plasma ascorbate concentrations.
    • To establish optimal vitamin C supplementation strategies for premature infants.

    Main Methods:

    • Plasma ascorbate levels were measured in 20 premature newborns.
    • Participants received varying daily intakes of vitamin C (less than 5 mg/kg, 5-10 mg/kg, or parenteral supplementation).

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  • Levels were monitored during the initial two weeks of postnatal life.

    • Main Results:

    • Low daily intake (<5 mg/kg) led to a significant decline in plasma ascorbate.
    • Moderate intake (5-10 mg/kg) resulted in higher plasma ascorbate levels compared to minimal intake.
    • Parenteral supplementation (50 mg/day) achieved the highest plasma ascorbate concentrations.

    Conclusions:

    • Premature infants may have increased vitamin C requirements due to maturational and environmental factors.
    • Early and adequate vitamin C provision is essential for preventing deficiency in premature newborns.
    • Tailored supplementation strategies are necessary to maintain optimal ascorbate status.