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Related Experiment Videos

Agoraphobia following amphetamine withdrawal

A Djenderedjian, R Tashjian

    The Journal of Clinical Psychiatry
    |June 1, 1982
    PubMed
    Summary

    Agoraphobia, a recognized psychiatric condition, can be triggered by discontinuing certain antidepressant medications. This case study highlights d-amphetamine

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    Area of Science:

    • Psychiatry
    • Pharmacology

    Background:

    • Agoraphobia, a clinically accepted entity since DSM-III, presents with prominent symptoms of phobia, anxiety, and depersonalization.
    • The exact etiology of agoraphobia remains unclear, with various theoretical explanations.
    • Recent literature suggests a link between pharmacologic agent use/discontinuation and agoraphobia onset.

    Observation:

    • Previous reports implicated tricyclic antidepressants in the development of agoraphobia.
    • This report details a case where agoraphobia emerged after discontinuation of d-amphetamine.
    • D-amphetamine, an "antidepressant," was identified as the causative agent in this instance.

    Findings:

    • Discontinuation of d-amphetamine precipitated the full syndrome of agoraphobia in the reported patient.
    • This finding expands the range of implicated pharmacologic agents beyond tricyclic antidepressants.
    • Suggests a potential causal relationship between d-amphetamine withdrawal and agoraphobia.

    Implications:

    • Clinicians should consider medication withdrawal, specifically d-amphetamine, as a potential trigger for agoraphobia.
    • Further research is warranted to explore the neurobiological mechanisms linking stimulant withdrawal to agoraphobic symptoms.
    • This case contributes to understanding the complex interplay between pharmacotherapy and psychiatric disorders.

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