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Related Experiment Videos

Outpatient opiate detoxification with clonidine

A M Washton, R B Resnick

    The Journal of Clinical Psychiatry
    |June 1, 1982
    PubMed
    Summary

    Clonidine effectively suppresses opiate withdrawal symptoms, enabling outpatient detoxification. Individualized dosing is crucial due to side effects, positioning clonidine as a transitional treatment before naltrexone therapy.

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    Area of Science:

    • Pharmacology
    • Addiction Medicine
    • Clinical Therapeutics

    Background:

    • Opiate addiction presents significant public health challenges.
    • Traditional detoxification methods often involve hospitalization and can be uncomfortable.
    • Non-opiate pharmacotherapies are sought for safer and more accessible detoxification.

    Purpose of the Study:

    • To evaluate the efficacy and safety of clonidine for outpatient opiate detoxification.
    • To assess clonidine's role as a transitional treatment towards naltrexone therapy.
    • To explore potential alternative alpha-2 noradrenergic agonists with improved side effect profiles.

    Main Methods:

    • Outpatient clinical studies involving opiate-dependent patients.
    • Administration of clonidine with individualized dosing based on blood pressure and symptoms.
    • A 10-day detoxification protocol followed by initiation of naltrexone treatment.

    Main Results:

    • Clonidine demonstrated safe and effective outpatient opiate detoxification.
    • The 10-day protocol facilitated abrupt opiate cessation and sustained abstinence for naltrexone initiation.
    • Sedative and hypotensive side effects necessitated individualized clonidine dosing.

    Conclusions:

    • Clonidine is a viable non-opiate option for outpatient opiate detoxification.
    • It serves as an effective bridge to naltrexone treatment.
    • Lofexidine shows promise as a potentially better-tolerated alternative for outpatient use.

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