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Predicting pharmacotherapy outcome by subjective response

E B Fink, W Braden, C B Qualls

    The Journal of Clinical Psychiatry
    |July 1, 1982
    PubMed
    Summary
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    Early subjective response to psychoactive medication predicts treatment success in functional psychoses. Assessing patient feelings after 24 hours can identify those likely to refuse drugs or show poor clinical outcomes.

    Area of Science:

    • Psychiatry
    • Clinical Psychology
    • Pharmacology

    Background:

    • Functional psychoses represent a significant challenge in psychiatric care.
    • Predicting treatment response is crucial for optimizing patient outcomes and resource allocation.
    • Early indicators of treatment efficacy are needed to guide therapeutic decisions.

    Purpose of the Study:

    • To evaluate the predictive value of initial subjective response to psychoactive medication on clinical outcome.
    • To identify early markers for potential drug refusal or clinical unresponsiveness in patients with functional psychoses.

    Main Methods:

    • A cohort of 33 drug-free patients with DSM-III functional psychoses was studied.
    • Subjective response to the first 24-hour dosage of psychoactive medication was assessed.

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  • Pretreatment evaluations included symptom severity, role functioning, and attitude towards treatment.
  • Clinical improvement was measured after 8-21 days of treatment.

    • Main Results:

    • A significant positive correlation was found between subjective response to initial dosage and clinical improvement.
    • Patients experiencing a positive early subjective response were more likely to show clinical improvement.
    • The study suggests early subjective response can be a predictor of treatment adherence and efficacy.

    Conclusions:

    • Inquiry into a patient's early subjective experience with psychoactive medication is valuable.
    • This assessment can help identify patients at risk for non-response or medication non-adherence.
    • Clinicians should consider early subjective response as a key factor in managing functional psychoses.