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Related Experiment Videos

Plasmapheresis and plasma cholinesterase

G J Wood, G M Hall

    British Journal of Anaesthesia
    |September 1, 1978
    PubMed
    Summary

    Plasma cholinesterase levels significantly decrease after plasmapheresis, dropping by 64% after one session. Frequent plasma exchanges can reduce levels to 8% of the initial value, warranting caution with cholinesterase-metabolized drugs.

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    Area of Science:

    • Biochemistry
    • Clinical Medicine
    • Pharmacology

    Background:

    • Plasma cholinesterase (E.C. 3.1.1.8) plays a crucial role in drug metabolism.
    • Plasmapheresis is a medical procedure involving plasma exchange.
    • The impact of plasmapheresis on cholinesterase levels is not fully understood.

    Purpose of the Study:

    • To quantify the reduction in plasma cholinesterase concentrations following plasmapheresis.
    • To assess the effect of repeated plasma exchanges on cholinesterase levels.
    • To provide guidance on the use of cholinesterase-metabolized drugs in patients undergoing plasmapheresis.

    Main Methods:

    • Measurement of plasma cholinesterase concentrations in nine outpatients undergoing regular plasmapheresis.
    • Monitoring cholinesterase levels in a patient receiving multiple plasma exchanges over a short period.

    Main Results:

    • A single plasmapheresis session resulted in a 64% decrease in cholinesterase concentration.
    • A patient undergoing four plasma exchanges in six days experienced a reduction in cholinesterase to 8% of the baseline level.

    Conclusions:

    • Plasmapheresis significantly reduces plasma cholinesterase activity.
    • Caution is advised when administering drugs metabolized by cholinesterase to patients undergoing plasmapheresis, especially with frequent exchanges.

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