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Related Experiment Videos

Clostridium difficile and cytotoxin in routine faecal specimens

J Q Nash, B Chattopadhyay, J Honeycombe

    Journal of Clinical Pathology
    |May 1, 1982
    PubMed
    Summary

    Routine stool sample analysis found Clostridium difficile in 69 patients, but toxin was detected in only ten. Co-infections with Salmonella were observed, though no C. difficile treatment was needed.

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    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Clostridium difficile is a significant cause of infectious diarrhea.
    • Routine surveillance for enteric pathogens is crucial in clinical settings.

    Purpose of the Study:

    • To investigate the prevalence of Clostridium difficile in routine fecal specimens.
    • To assess the co-occurrence of C. difficile with other common enteric pathogens.
    • To determine the clinical significance and treatment needs for C. difficile infections.

    Main Methods:

    • Analysis of 1239 unselected fecal specimens over a five-month period.
    • Bacterial culture for isolation of Clostridium difficile, Salmonella, Campylobacter, and Shigella.
    • Toxin detection assays for C. difficile.

    Main Results:

    • Clostridium difficile was cultured from 69 patients (5.6%).
    • C. difficile toxin was detected in only 10 patients (0.8%).
    • Co-infection with Salmonella occurred in 12 patients; no specific C. difficile treatment was required for any patient.

    Conclusions:

    • Clostridium difficile is frequently isolated from routine stool samples, but toxin production is less common.
    • Co-infections with other enteric pathogens like Salmonella are possible.
    • The clinical significance of C. difficile isolation without toxin detection warrants further investigation.

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