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Leukoderma in the nude C57BL/6 mouse

J J Nordlun, A Ackles

    The British Journal of Dermatology
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    The nu gene in C57BL/6 mice causes athymia and hairlessness. Homozygous mice develop leukoderma due to normal hair shedding, distinct from vitiligo.

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    Area of Science:

    • Genetics
    • Immunology
    • Dermatology

    Background:

    • The nu gene induces athymia and a nude phenotype in mice.
    • C57BL/6 mice are commonly used models for genetic research.

    Purpose of the Study:

    • To characterize the phenotype of C57BL/6 mice homozygous for the nu gene.
    • To investigate the cause of leukoderma observed in these mice.

    Main Methods:

    • Phenotypic analysis of C57BL/6 mice with the nu gene.
    • Histological examination of skin and hair follicles.

    Main Results:

    • Homozygous C57BL/6 nu/nu mice exhibit runting, hairlessness, and leukoderma by 6 weeks.
    • Leukoderma is attributed to the shedding of short, stubby hairs during a normal hair cycle.

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  • The observed leukoderma is differentiated from vitiligo, which involves melanocyte destruction.

    • Conclusions:

    • The nu gene in C57BL/6 mice results in a distinct phenotype including hair loss and a specific type of leukoderma.
    • This phenotype is a consequence of normal hair cycle processes and not autoimmune destruction of melanocytes.