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Related Experiment Videos

Psoriasis and occlusive vascular disease

C J McDonald, P Calabresi

    The British Journal of Dermatology
    |November 1, 1978
    PubMed
    Summary

    Psoriasis patients show a higher rate of occlusive vascular disease, including heart attack and stroke. This suggests psoriasis may predispose individuals to these serious vascular conditions, especially males.

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    Area of Science:

    • Dermatology
    • Cardiovascular Medicine
    • Epidemiology

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • The association between psoriasis and occlusive vascular disease requires further investigation.

    Purpose of the Study:

    • To test the hypothesis that psoriasis is linked to an increased incidence of occlusive vascular disease.
    • To determine if psoriasis predisposes patients to vascular events.

    Main Methods:

    • Retrospective analysis of clinical records.
    • Comparison of 323 psoriatic patients with 325 non-psoriatic patients.
    • Examination of occlusive vascular disease incidence (thrombophlebitis, myocardial infarction, pulmonary embolization, cerebrovascular accident).

    Main Results:

    • Occlusive vascular disease occurred significantly more often in psoriatic patients than non-psoriatic patients.
    • This association was particularly pronounced in the male psoriatic population.
    • Psoriatic patients with predisposing factors faced a higher risk of vascular episodes.

    Conclusions:

    • Psoriasis is associated with a greater incidence of occlusive vascular disease.
    • Psoriasis appears to be a predisposing factor for vascular disease.
    • Risk stratification for vascular events is crucial in psoriatic patients.

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